Проведене дослідження є експериментально-клінічним, виковано на лабораторних щурах та присвячено меті визначення рівня простогландину Е-2 та лейкотрієну В-4 в плазмі крові та тканині нирок тварин з гострим пієлонефритом на тлі супутнього гіперглікемічного стану для моніторингу розвитку та перебігу запального процесу та оцінки ефективності медикаментозного впливу.
This study is experimental and clinical, performed on laboratory
rats and is dedicated to the purpose of determining the level of
prostaglandin E-2 and leukotriene B-4 in the blood plasma and
kidney tissue of animals with acute pyelonephritis against the
background of a concomitant hyperglycemic state for monitoring
the development and course of the inflammatory process and
assessing the effectiveness drug influence. The renal tissue contains
a significant amount of prostaglandins and is actively involved in
their synthesis and metabolism, regulating the inflammatory
reactions and tone of the upper urinary tract, maintaining a normal
balance between different groups of PGs, which have
multidirectional physiological effects. It was found that in acute
pyelonephritis in rats, a significant increase in the level of
prostaglandin E2 in blood plasma by 106.4% and kidney tissue by
48.9%, and leukotriene B4 in blood plasma by 54.8% and in
kidney by 27.5% was revealed. compared to the norm. It should
be noted that the use of etiotropic-pathogenetic drug action
contributed to a significant decrease in the levels of PGE2 and
LV4 in the blood plasma and in the kidney tissue of rats with
reproductive acute pyelonephritis and diabetes mellitus, which
indicates the effectiveness of the proposed drug effect on the
course of the infectious and inflammatory process and prevention
of the development of severe renal complications due to concomitant
hyperglycemic conditions.
