Abstract:
The social role of the problem of obesity is determined by the threat of disability and a
decrease in overall life expectancy due to the frequent development of serious concomitant
diseases. Despite a significant number of studies on the effect of excess body weight on the
level of 25(OH)D, there are still ongoing discussions about the role of vitamin D in the
pathogenesis of obesity. The main described pathogenetic mechanism by which obesity
negatively affects 25(OH)D levels is the redistribution of fat-soluble vitamin D in large
amounts of adipose tissue. This leads to a decrease in the concentration of 25(OH)D in the
blood serum.
Goal. To determine the dependence of the level of 25(OH)D in blood serum on
anthropometric indicators in residents of the southern regions of Ukraine. Materials and methods. During the study, 928 residents (women – 507; men – 421) of
southern Ukraine aged 19 to 82 were examined.
The results. The level of 25(OH)D in blood serum among the study participants ranged
from 4.31 - 89.19 ng/ml. The prevalence of deficiency, insufficiency and sufficient level of
vitamin D in the study group was 33.6%, 33% and 33.4%, respectively. The body mass index
in the study group ranged from 16.1 kg/m2 to 41.3 kg/m2, while the average BMI in men was
25.2±4.0 kg/m2, and in women it was 25.6±4.5 kg/m2. In addition, an anthropometric
analysis was conducted, namely, a waist-to-hip ratio assessment was conducted in order to
determine the influence of these indicators on the level of 25(ОН)D in blood serum.
Conclusions. A higher negative correlation was established between the level of
25(OH)D and BMI than the waist-to-hip ratio index. The hypothesis of the connection of
vitamin D with the specified anthropometric indicators was confirmed, in particular, when
comparing groups by BMI. It is worth noting that among people of both sexes, regardless of
age, with an increase in BMI and waist circumference, a decrease in the level of 25(OH)D in
blood serum is observed.
