Physiological Basis of Human Longevity: the Concept of a Cascade of Human Aging Mechanism

Abstract

The research is devoted to the fundamental issue of medicine and biology – the study of factors limiting the life span of a person. As a model, the system of adaptation of the human body to the forces of natural gravity is chosen, the disadaptation to which manifests itself in falls and everyday injuries. The object of the study was the selection of severe fractures of bone tissue due to fall, taken in the age aspect. Statistical and meta-analytical research methods were used. It is shown that the age-related increase in mortality due to household falls, coming to severe bone fractures, is non-linear and increases in geometric progression. As a result of the coincidence of the age characteristics of bone fragility and age-related kidney function, an assumption is made about the role of involution of the renal tissue in the development of osteoporosis in the elderly and the need for a new approach to the prevention of osteoporosis and domestic injuries.