Comparative nephroprotective efficiency of polyfunctional mucous-adhesive phytogels

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dc.contributor.author Gozhenko, A. I.
dc.contributor.author Levitsky, A. P.
dc.contributor.author Stepan, V. T.
dc.contributor.author Selivanskaya, I. A.
dc.contributor.author Pustovoit, I. P.
dc.date.accessioned 2021-06-04T08:08:39Z
dc.date.available 2021-06-04T08:08:39Z
dc.date.issued 2021
dc.identifier.citation Gozhenko A. I., Levitsky A. P., Stepan V. T., Selivanskaya I. A., Pustovoit I. P. Comparative nephroprotective efficiency of polyfunctional mucous-adhesive phytogels. Journal of Education, Health and Sport. 2021;11(1):24-32. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.1.002 uk_UA
dc.identifier.uri https://repo.odmu.edu.ua:443/xmlui/handle/123456789/9547
dc.description.abstract Aim. To compare the nephroprotective effect of oral applications of different phytogels in experimental kidney pathology. Methods. We used phytogels: "Kvertulin" (quercetin + inulin + calcium citrate), "Biotrit" (juice from wheat germ) and "Dubovy" (extract from oak wood). Experimental models were reproduced in rats: diabetic syndrome, prednisolone immunodeficiency, intoxication with thermal peroxide sunflower oil. The condition of the kidneys was assessed by changes in the level of biochemical markers in the kidney tissue (elastase, urease, lysozyme, MDA, the degree of dysbiosis). Results. Experimental pathologies cause an increase in the level of elastase, urease, MDA, the degree of dysbiosis, and a decrease in lysozyme activity in the kidneys. Oral application of phytogels caused a decrease in the activity of elastase, urease, MDA content and the degree of dysbiosis, but increased the activity of lysozyme. When recalculating the degree of decrease in elastase activity and increase in lysozyme activity per 1 g of phytogel or 1 mg of active principle (quercetin or the amounts of polyphenols), phytogel "Kvertulin" turned out to be the most effective anti-elastase agent, and phytogel "Biotrit" turned out to be the most effective lysozyme-reducing agent. Conclusion. Oral applications of multifunctional mucous-adhesive gels have a nephroprotective effect in experimental kidney pathology. uk_UA
dc.language.iso en uk_UA
dc.subject kidney uk_UA
dc.subject nephroprotection uk_UA
dc.subject phytogels uk_UA
dc.subject stomatotropic therapy uk_UA
dc.subject quercetin uk_UA
dc.subject plant polyphenols uk_UA
dc.title Comparative nephroprotective efficiency of polyfunctional mucous-adhesive phytogels uk_UA
dc.type Article uk_UA


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