Abstract:
The article is devoted to the role of estrogen (ER) and progesterone (PR) receptors in the pathogenesis of adenomyosis (AМ) in the presence of the endometrioid carcinoma of uterine (ECU) in postmenopausal women. The research material included the uterus removed from 17 patients (52-74 years old) with AМ and ECU. An іmmunohistological study was performed to determine the state of the ER and PR. The study of the euand
ectopic endometrium receptor apparatus revealed the presence of both in the epithelial cells and in the stromal cells, indicating the hormonal dependence of AМ and the key role of steroid hormones in the development of intraocular endometriosis in postmenopausal women. An increased level of ER and PR activity was detected respectively to the improvement of differentiation degree of the eutopic endometrium epithelial cells. It has been established that limited estrogenic and expressed progesterone receptor activities are pathogenetically significant for AМ.
